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Patients should discuss their complete medical history with their provider to ensure GLP-1 treatment is appropriate

Concurrently, GLP-1 stimulates the translocation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus via the PKA/ERK signaling pathway, where Nrf2 induces transcription of genes for SOD, GPx, catalase, thioredoxin, and other antioxidant enzymes, further enhancing the cellular antioxidant defense system

If 2.5 mg is producing good results with minimal side effects, there is no rush to increase

It is possible that the therapeutic reduction of ICP in the exenatide arm impacted cognitive scores at 12 weeks, as a prior publication showed the beneficial effects of ICP reduction on cognition [6]

[DOI] [PubMed] [Google Scholar] 60.Serretti A., Mandelli L

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