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There is no absolute contraindication, and the combination is commonly prescribed in UK clinical practice for patients with both cardiovascular conditions and type 2 diabetes, though individualised medical assessment is essential

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According to the American Diabetes Association's Standards of Medical Care in Diabetes, proper injection technique and systematic site rotation are essential for optimal medication absorption and to prevent lipohypertrophy (thickening of fatty tissue) or lipoatrophy (loss of fatty tissue) at injection sites

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