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Patients should seek urgent medical attention for severe persistent abdominal pain (especially if radiating to the back), persistent vomiting, jaundice, fever, inability to pass stool/gas, or abdominal distension, which could indicate serious complications such as pancreatitis, gallbladder disease, or intestinal obstruction

The BRAT diet is an acronym that stands for banana, rice, applesauce and toast, Michelle Jaelin, registered dietitian in Ontario, Canada, tells TODAY.com Its rooted in the principle that these bland, easily digestible foods can help soothe the digestive system, firm up stools and reduce the frequency of bowel movements, adds Jen Messer, president of the New Hampshire Academy of Nutrition and Dietetics and registered dietitian at Jen Messer Nutrition

The combination may increase the risk of hypoglycemia, especially in elderly patients or in patients with renal impairment

Genetic variants in key incretin and cardiovascular pathwayssuch as GLP1R, GIPR, TCF7L2, APOE, and IL6modulate therapeutic response and safety profiles, highlighting the critical role of pharmacogenomics

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