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Higher doses of GLP-1R agonists can achieve clinically relevant weight loss, and greater increases in dose levels, in theory, can drive more weight-lowering efficacy

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Published March 26, 2024

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Tirzepatide, the newest dual GLP-1/GIP receptor agonist, has a similar 5-day half-life, but limited data suggest potentially less gastric emptying delay compared to pure GLP-1 agonists due to dual receptor activation [30]