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The resulting 1st generation GLP-1 agonists were introduced with the approval of Amylins Byetta (exenatide) in 2005 and Novos Victoza (liraglutide) in 2010 in adults with type 2 diabetes

Slower titration improves tolerability at the cost of delayed maximum efficacy

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4% were of Hispanic or Latino ethnicity

GLP-1 and dopamine crosstalk was shown in rat WAT explants, since dopamine upregulated GLP-1-induced AMPK activity in mesenteric WAT in the presence of the D2R and D3R inhibitor Domperidone