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Rhythm also announced that it has initiated a Part D arm in the Phase I trial of MC4R agonist RM-718 that will enroll up to 20 patients with PWS

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Opportunity to serve users According to the European Medicines Agency, there are currently three branded GLP-1 drugs approved for use in weight management in Europe: Saxenda, Wegovy and Mounjara

Additional indications Knee osteoarthritis, sleep apnea, MASLD, cardiovascular outcomes, and chronic low back pain would follow based on their respective trial timelines This mirrors how Lilly handled tirzepatide: Mounjaro was approved for diabetes first (May 2022), followed by Zepbound for obesity (November 2023)

A sizeable proportion of the eligible patients in the database could not be PS matched owing to missing HbA1c and weight data and were therefore not included in the analysis