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doi: 10.1001/jamanetworkopen.2024.57232

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Our findings should be viewed as being significant but tentative, as future studies are needed to examine these questions in a much larger and more diverse population. Experts agree that the potential risk of NAION should not deter the use of semaglutide medications to treat diabetes or obesity

Unlike previous meta-analyses that incorporated non-randomized studies, unpublished trials, or a mixture of study types, our analysis strictly included only RCTs, the highest level of clinical evidence
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Two classes of prescription medications frequently discussed are the GLP-1 receptor agonists (including Semaglutide, Ozempic, and Wegovy) and the stimulant phentermine
