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A blockbuster GLP-1 faces fresh scrutiny over rare optic nerve risk.

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Initial treatment withacetazolamide was discontinued due to intolerance.Exenatide was subsequently initiated, leading to early improvement in headache frequency and diplopia, independent of weight loss

After synthesizing the chimeric GLP-1A-conjugated oligomeric DOCAs (mD-G1A, bD-G1A, and tD-G1A) using a maleimide reaction, in vitro cellular permeability and insulinotropic effects were assessed
