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Nat Neurosci 8:571578 Kristensen P, Judge ME, Thim L, et al (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin

In preclinical models of pancreatic cancer, Zhao et al

Thus, while thyroid safety remains under surveillance, the broader evidence suggests that the benefits of GLP-1RAs extend beyond glucose lowering to encompass immunometabolic effects that could plausibly influence AITD (Figure 1)

The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

provided evidence suggesting a moderate increase in the relative risk of thyroid cancer with GLP-1 RAs treatment

Junction PCR assay Genomic DNA extracted from Hepa1-6 cells or mice liver was used as the PCR template for the junction PCR assay