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Line profile analysis showed that apical membrane ENaC expression was increased in DKD patients with neither agents and those with SGLT2is alone, but that was inhibited by the combination therapy of SGLT2is and DPP4is (Fig

Recent randomized controlled trials show that combining GLP-1RAs with exercise yields additive benefits, including greater reductions in metabolic syndrome severity, abdominal obesity, oxidative stress and inflammation, and improved weight loss maintenance after cessation of pharmacotherapy (16, 17, 19, 21)

Acknowledgement The author wishes to thank Daniel Soares Freire, MD, PhD for providing medical writing and editorial assistance on behalf of Springer Healthcare

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Hiromura, M