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10.1038/s41591-023-02344-1 26 GarberA.HenryR.RatnerR.Garcia-HernandezP

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Sciences 2023 Breakthrough: GLP-1R Agonists 2024-08-13 Rapid increase in obesity rate is becoming a global public health crisis [1]

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness

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This method can reveal subtle conformational differences between peptide variants
