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Furthermore, the SELECT trial showed a 20% reduction in major adverse cardiovascular event risk in patients with obesity and without diabetes who lost weight with semaglutide treatment 10

Knudsen was not the only one interested in obesity at Novo Nordisk

Future research should aim to unravel the precise molecular mechanisms underlying these weight-independent benefits, enabling the development of new therapies that harness these anti-inflammatory pathways and potentially bypass the limitations of current interventions

Body weight, median (IQR), remained stable during the study period (65.8 kg [55.377.5] and 65.3 kg [56.5-78.5] for dulaglutide and placebo, respectively)

v24i9e39741 [DOI] [PMC free article] [PubMed] [Google Scholar] 28.Huntriss R, Haines M, Jones L, Mulligan D

The psychological journey of weight gain in psychosis