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However, since MNs needed to accurately locate the sensor-tissue contact point, which would be very demanding on the operators skills, and miniaturized sensors might be interfered with by environmental noise, and multichannel systems needed to be supported by complex signal processing algorithms, data fusion was difficult, and the long-term electrochemical stability of the MN electrodes such as oxidation of alloys as well as the continued reliability of the sensors in organoid cultures still needed to be verified

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ISBN 978-0-7020-5515-7

10.1016/S1353-8020(11)70065-7

at the same time, andrographolide can activate adenylate cyclase to promote the formation of cAMP and activate protein kinase A (PKA) to promote glycogen synthase kinase-3 (GSK-3) phosphate inactivation of HO-1, which weakens the negative regulation of Nrf2 by GSK-3 and maintains the continuous activation of HO-1 ( 4.3 Liver fibrosis Any liver injury will develop into liver fibrosis during the healing process, and if the condition persists for a long time, it can develop into liver cirrhosis

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