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This review aims to familiarize anaesthetists with these novel drug classes and to present current recommendations from professional organisations

Insulin resistance deepens

Here, we present evidence in -cells and primary mouse and human islets which demonstrates that, following agonist binding and internalisation, endosomal GLP-1R binds to endoplasmic reticulum (ER)-localised ER-mitochondria membrane contact site (ERMCS) organising factor VAPB to engage SPHKAP, a PKA-RI-specific A-kinase anchoring protein (AKAP) whose gene coding variants have previously been linked to T2D and high BMI risk in genome-wide association studies (GWAS)

MAbs Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

International Journal of Molecular Sciences, 21 (13), 4744

Compounded formulations have not been individually evaluated by the FDA for safety, effectiveness, or quality