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A 2025 meta-analysis synthesising multiple discontinuation studies found that after one year off GLP-1s, people regain approximately 60% of weight lost
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Vascular and systemic inflammation accelerate small-vessel disease, blood-brain barrier injury, and neuroinflammation all implicated in cognitive decline
If this is the case, you might have to invest in a more costly solution, such as a battery-powered cooling bag
doi: 10.1161/STROKEAHA.113.000990 49 ZhangLGuoZWuMHuXXuYZhouZ
