weight regain tirzepatide Demonstrates Sustained Loss but Discontinuation Results in Weight Regain: SURMOUNT-4 Trial GLP-1 Study is an EPIC

Weeks Tirzepatide dose Notes 14 2.5 mg Initiation only (not for glucose/weight effect) 58 5 mg First maintenance option 912 7.5 mg Increase as tolerated 1316 10 mg Maintenance option 1720 12.5 mg Increase as tolerated 21+ 15 mg (max) Maximum maintenance dose These steps follow the Mounjaro FDA label and Zepbound FDA label

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Hernndez-Cascales J

Don't reach for it as a first-line fix

In Quebec, where one in four adults is obese, the current cost of these new drugs (approximately $500 per month) would involve an annual expenditure of several hundred million dollars (in the United States the situation is even worse: the cost of a 72-week course of tirzepatide (15 mg/week) is approximately US$17,000, while the 68-week treatment with semaglutide (2.4 mg/week) is nearly US$23,000!)

Despite the promise of these medications, their benefits remain out of reach for many Black Americans, exacerbating health disparities in obesity and diabetes

I eat out at restaurants several times per week, but I almost never had fast food