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The use of CRISPR (clustered regularly interspaced short palindromic repeats) and adeno-associated viruses in gene therapy is now being pursued by multiple drug sponsors for the treatment of rare and chronic diseases and conditions

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

When to Seek Advice Contact your GP or diabetes specialist nurse if you experience: Persistent nausea or vomiting that prevents adequate fluid intake (risk of dehydration) Severe, persistent abdominal pain stop taking the medication and seek urgent medical attention as this could indicate pancreatitis Symptoms of hypoglycaemia if taking alongside insulin or sulfonylureas Severe abdominal pain radiating to the back, with or without fever or jaundice (yellowing of skin/eyes) may indicate gallbladder problems Unexplained weight loss or gain outside expected parameters If you're planning pregnancy, discuss with your healthcare provider

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The incretin effect is exclusively glucose-dependent and critical for the maintenance of glucose homeostasis

K., Hall, W