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These trials have enriched the therapeutic landscape for T2D patients, offering a range of GLP-1 receptor agonists with varying cardiovascular profiles, thus allowing clinicians to personalize treatment for each patient

For instance, a 2015 study found that Ozempic (semaglutide) did not affect the levels of oral birth control available in the bloodstream

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are incretins, gut-derived hormones that are released in response to nutrient ingestion to stimulate pancreatic glucose-dependent insulin secretion

Apart from hormonal levels, the bioactivity of IGF-1 is modulated by its binding proteins within the circulation

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A study indicated that exenatide significantly reduced fMRI alcohol cue reactivity in key brain regions, such as the ventral striatum and septal area, which are important for drug reward and addiction-regions with high GLP-1 receptor expression