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Y = years, mg = milligrams, mcg = micrograms, n = number of subjects, BMI = body mass index, NASH = non-alcoholic steatohepatitis, NAFLD = non-alcoholic fatty liver disease, kg = kilograms, ALT = alanine aminotransferase, AST = aspartate transaminase, LFF = liver fat fraction, T2DM = type 2 diabetes mellitus, PCOS = polycystic ovary syndrome, NR = not reported

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In a randomised phase 3 trial (NCT03052608) for advanced ALK-positive non-small cell lung cancer, 71% of the patients with brain metastases who received lorlatinib had an intracranial complete response 76

Cureus 15(6): e40179

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