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01Personal or family history of medullary thyroid carcinoma 02Multiple Endocrine Neoplasia syndrome type 2 (MEN-2) 03History of severe pancreatitis 04Currently pregnant, planning to become pregnant, or breastfeeding 05Severe gastrointestinal disease (gastroparesis, severe IBD) 06Under 18 years of age What's the catch

At 2 years, GLP-1 RA use was associated with an absolute risk increase for psoriasis of 0.05%, rising to 0.08% at 4 years

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Another was linked to a rise in blood pressure, and third had to be taken off the market after it was linked to an increased risk of suicide