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This powerful mechanism drives weight loss but can also reduce bowel movement frequency, causing constipation in roughly one in five patients during the first weeks of therapy

No, the elimination half-life remains constant at approximately seven days regardless of dose

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3, 2022, pp

Gorboulev V, Schrmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, Parker HE, Gribble FM, Reimann F, Lang F, Wiese S, Sabolic I, Sendtner M, Koepsell H