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Naltrexone-bupropion ( Contrave ): Constipation has been reported in over 19% of people taking Contrave

Many trial participants showed continued weight loss at 48 weeks with no clear plateau

There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop, said senior author Ziyad Al-Aly, MD, a WashU Medicine clinical epidemiologist and chief of the Research and Development Service at the VA Saint Louis Health Care System

Neuronally produced GLP1 is transported to the axon terminals of the producing cells and is there stored in synaptic vesicles until its eventual release into the synaptic cleft, or in case of extrasynaptic release, into the brain parenchyma (Zheng et al., 2014)

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are transforming the way we approach weight loss

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