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Differences in metabolic parameters and cardiovascular risk between American Diabetes Association and World Health Organization definition of impaired fasting glucose in European Caucasian subjects: a cross-sectional study

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However, these findings represent observational correlations rather than established causality and require confirmation through randomized controlled trials [184]

80 However, adverse event reporting systems are inherently limited by underreporting, confounding, and reporting bias, and cannot establish causality

55 In a broad sense, these findings suggest that effects of GIP on cardiac remodeling may differ based on the ambient pathophysiologic milieu