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GLP-1 injected subcutaneously simply took too long to reach receptors on target tissuesDPP-4 degraded the peptide within minutes

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Yang F., et al
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CrossRef Adverse kidney events with initiation of SGLT2 inhibitors versus DPP4 inhibitors in diabetic people with a history of acute kidney injury YiWei Kao, TzeFan Chao, YuWen Cheng, ShaoWei Chen, YiHsin Chan European Journal of Clinical Investigation.2025;[Epub] CrossRef The Potential Effect of Dapagliflozin and Liraglutide in Attenuating Cardio-Renal Injuries in Diabetic Rats Adel Albanna, Doaa Ibrahim, Amani Shamsher, Mojahed Al-Shawia, Abdulsalam Halboup Journal of Experimental Pharmacology.2025

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The inclusion of enavogliflozin in DWP306001 is significant, as it is an SGLT-2 (sodium-glucose co-receptor 2) inhibitor