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Tirzepatide vs Semaglutide: At a Glance Tirzepatide vs Semaglutide: Dosage & Administration While both Tirzepatide and Semaglutide are administered as subcutaneous injections , there are key differences in dosing, titration, and available formulations that influence patient preference and tolerability

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Furthermore, the increased molecule size resulting from IgG4-Fc linkage reduces the elimination rate92)

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doi: 10.1021/mp400256h 22 KatrusiakAKatrusiakA

This dual mechanism results in greater weight loss and glycemic control than GLP-1 alone (Jastreboff et al., 2022)