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Option 3: Accept a lower maintenance dose If 12mg is persistently intolerable after repeated attempts, 8mg is a clinically reasonable maintenance dose

The cost-effectiveness of pharmacotherapy and lifestyle intervention in the treatment of obesity

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, et al

Notably, SCFA-mediated GLP-1 release was abolished in Gpr43 -deficient mice, confirming receptor dependency (Psichas et al., 2015)

10.1016/S0140-6736(12)60479-6 25 GaoL.LeeB

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