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Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/AKT): Actions and defects in obesity and type II diabetes
For semaglutide , a phase 2 trial published in the New England Journal of Medicine (2021) examined daily semaglutide 0.4 mg in NASH patients and found that 59% achieved NASH resolution compared to 17% with placebo
Thus GLP-1, GLP-1R agonists, and DPP-4 inhibitors might have important roles as mediators of inflammation
"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA." The Lancet, vol
The short answer: It can help but not in the way most people think
Currently, large-scale randomized clinical trials are underway to assess tirzepatides efficacy in facilitating weight loss among children with a BMI at or above the 85th percentile for age and sex (SURMOUNT-ADOLESCENTS trial)
