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5 GLP-1 trends to expect in 2026: Expanded uses, oral options, and more Originally developed for Type 2 diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists have transformed the weight-loss medication market

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combination data is nonexistent Safety first Overlapping side effect profiles create legitimate concerns about additive adverse events Patience pays Phase 3 trials for both compounds are ongoing

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Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity

Once opened, Wegovy can be out of the fridge for 6 weeks , but it cannot reach temperatures of 30C or above and should be kept away from direct light