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doi: 10.1038/d41573-022-00001-9

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Nonetheless, certain conditions in patients with MB can set up an oxygen supply-demand mismatch severe enough to lead to myocardial ischemia: Exercise-related stress leads to tachycardia which can decrease diastolic filling time for the coronary arteries and lead to more of the cardiac cycle to be spent in systole Myocardial hypertrophy and diastolic dysfunction can affect the transmural perfusion gradient increasing supply-demand mismatch

There are also many concerns about the long-term effects of GLP-1s, especially for non-diabetic users