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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

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Nearly 12% of Americans have used GLP-1 drugs for weight loss, including about one-fifth of women aged 50 to 64, according to report from the RAND Education and Labor division

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AN is obesity's metabolic bookend. That connection explains why GLP-1 agonists carry serious risks for those predisposed to AN and with at least one in eight American adults now taking these drugs, the stakes couldn't be higher