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Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

Compounded GLP-1 medications like semaglutide and tirzepatide may include additives such as B12, B6, glycine, and NAD to improve comfort, energy, and tolerability.

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