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That design may improve stomach tolerability for some people, although it does not remove all gastrointestinal risk

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The clearance rate is not significantly affected by renal impairment

By targeting two separate hormones, Tirzepatide may be able to do more to help regulate appetite and improve metabolism

Endocrinology 133(6):28612870 Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, Friedman SL, Diago M, Romero-Gomez M (2015) Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis