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In intestinal L-cells and neurons of the NTS, a specific isoform of PC, PC1/3, is predominantly expressed and yields GLP-1, oxyntomodulin, and GLP-2 as the physiologically relevant products (134, 228, 238)

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Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI

It can also lead to skin thickening and lumps of fat tissue developing under the skin, called lipohypertrophy

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Generally, the ARC is responsible for transmitting leptin signals to the hypothalamus and other brain regions for regulating the energy balance and metabolic homeostasis [14]