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( C ) FAO in caSMCs was measured with a Seahorse extracellular flux analyzer as the OCR within 24 hours of transfection with MTP siRNA (gray bars) or control siRNA (white bars) and pretreated with 100 nM GLP-1(2836) twenty minutes before the mitochondrial stress test

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As weight loss increases the lithogenicity of bile, it remains unclear whether the increased risk of biliary disease seen with GLP-1 receptor agonists is due to the medication itself or to weight loss