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Challenges such as solubility limitations and non-specific binding must be carefully managed

Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin

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Activation of murine preproglucagonproducing neurons reduces food intake and body weight

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Another approach to optimize weight loss including in diabetes involves the use of a combination of a GLP-1 receptor agonist and a long-acting analog of the cell hormone amylin, known as cagrilintide