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If youre still working toward your goal weight or experienced weight regain over the years, youre not aloneand youre not out of options

GLP-1 is an abbreviation for Glucagon-Like Peptide-1 receptor agonist, which is a class of medications commonly used to treat diabetes and to assist with weight loss in patients with or without diabetes

Keep a simple log and share observations at your 4-week and 8-week follow-ups with your PlexusDx provider

Obes Surg 34(10):38883896 [DOI] [PubMed] [Google Scholar] 59.Kellett J et al (2025) The efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists for insufficient weight loss or regain after metabolic/bariatric surgery: a systematic review and meta-analysis

Partial leptin reduction achieved by either partial genetic deletion of the leptin gene in adipose tissue or the administration of a leptin neutralizing antibody slows down body weight gain and improves glucose tolerance

They typically happen for one of two reasons