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GLP-1 stimulation of insulin gene expression was first reported by Daniel Drucker in rat insulinoma RIN1046-38 cells [82] and was subsequently confirmed in several independent studies [372,373,463,464]

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Further randomized controlled trials (RCTs) or large-scale database analyses are needed to confirm these observations and guide clinical recommendations

Mechanisms underlying the blood pressure lowering effects of dapagliflozin, exenatide, and their combination in people with type 2 diabetes: a secondary analysis of a randomized trial

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Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in Db/Db Mice