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The medications work by affecting blood sugar and can cause low blood sugar in some patients, particularly when combined with other drugs for type 2 diabetes

Clinical trials show average losses of 1015% of starting body weight in the first four months, though individual outcomes vary widely based on genetics, adherence, and personal factors

A 2025 systematic review mapped weight change after stopping anti-obesity medicines across 11 RCTs

Clinical Evidence: Semaglutide and Inflammation Reduction A 2023 analysis of cardiovascular outcome trials demonstrated that GLP-1 receptor agonists, including semaglutide, reduced inflammatory biomarkers independent of glycemic control or weight change