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Long-term PPI use carries known risks including reduced B12 and magnesium absorption, increased fracture risk, and potential alterations in gut microbiota diversity

47 In addition, despite high leptin production in response to overeating, leptin responsiveness becomes blunted in those with obesity and insulin resistance, such that high circulating leptin levels lose their impact on appetite and metabolism, resulting in a state described as leptin resistance

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10.2165/11209750-000000000-00000 108 ScrocchiL

If you are considering semaglutide GLP-1, you should understand that its not designed to be an instant fix

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