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Published 25 May 2026 Reading time 16 minutes Last reviewed 25 May 2026 TRIUMPH-1 Phase 3 n = 2,339 "The largest weight loss ever observed for a non-surgical obesity treatment" 28.3% Average body weight loss (12 mg, 80 weeks) 30.3% Average weight loss (BMI 35 extension, 104 weeks) 45.3% Of 12 mg participants past the 30% threshold 24.1 cm Average waist circumference reduction at 12 mg The 30-second version What happened: On 21 May 2026, Eli Lilly published topline TRIUMPH-1 Phase 3 results for retatrutide

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Increases Energy Expenditure via Glucagon Receptor Activation What sets retatrutide apart is its activation of the glucagon receptor, which is associated with increased energy expenditure and fat utilization

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