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Our study demonstrates that STZ-induced DNP led to a significant increase in the serum levels of all three pro-inflammatory cytokines TNF-, IL-1 and IL-6, and our findings align with prior research indicating that uncontrolled hyperglycemia triggers a series of inflammatory responses in STZ-DNP rats [55]

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1,2 The most potent stimuli for glucagon secretion are hypoglycemia, prolonged fasting, exercise, and after a protein-rich meal

Second, it limits excess glucose production in the liver by suppressing glucagon release
