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Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors
Biological Psychiatry, 85, 872-880
One dynamic that we and investors will be closely monitoring is the potential tailwind to branded GLP-1 drugs for obesity when compounded versions can no longer be sold in the US, as of May 22, 2025
The needle is tiny, and most people report that the injection is relatively pain-free
Both are FDA-approved GLP-1 medications
Your optimal choice depends entirely on your medical history, your budget, and your long-term goals
