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The prevalence of chronic pain in Europe was estimated to be 26% according to a European study on pain involving 3849 phone calls and 300 indepth interviews [32]

It plays a crucial role in detoxifying harmful free radicals, strengthening immunity, and supporting overall skin health
Therefore, the presence and activity of specific gut microbes capable of metabolizing hesperidin to hesperetin are key determinants of hesperidin bioavailability

Abstract Many studies have demonstrated the association of oxidative stress caused by excessive and sustained production of reactive species with chronic inflammatory conditions, neurodegenerative diseases, diabetes mellitus, atherosclerosis, and cancer

These studies highlight the critical role of miRNAs in DR development, making them potential therapeutic targets for DR management

Kalichman L, Zhu Y, Zhang Y, et al
