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This finding aligns with previous studies, suggesting that short-acting agents may more readily cross the blood-brain barrier, thereby activating central GLP-1 receptors and exacerbating symptoms such as nausea and anorexia ( , dosed twice daily), which likely contributes to its higher vomiting risk due to frequent dosing and greater fluctuations in plasma concentrations

Studies were eligible if they compared the efficacy of GLP-1 RAs, such as liraglutide or exenatide, with placebo, no treatment, or any other intervention, including testosterone replacement therapy (TRT)

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