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These finding suggested that endotoxin, frequently released in the ESRD setting, may consistently cause damage to the mesothelial layer, potentially leading to PD failure

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GLP-1RAs thus prevent the occurrence of retinal damage associated with oxidative-stress-induced activation of glial cells and collectively foster a healthy retinal microenvironment by virtue of preventing cellular overexertion [94, 100]

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Upon activation by GLP-1RA, the receptor stimulates cAMP production, which activates the PKA pathway and modulates the ERK1/2 signaling cascade

23-25 To resolve this confusion, the prospective FOCUS trial was initiated in 2019