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Both tirzepatide and semaglutide were associated with increased risk of gastrointestinal adverse events compared with placebo at all doses, tirzepatide 15mg was associated with the highest risk for nausea (3.6 times), vomiting (4.4 times) and diarrhoea (2.0 times)

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Week 1: Right thigh, upper-outer quadrant Week 2: Left thigh, upper-outer quadrant Week 3: Right thigh, lower-front quadrant Week 4: Left thigh, lower-front quadrant Week 5: Right thigh, upper-front quadrant Week 6: Left thigh, upper-front quadrant Week 7: Right thigh, lower-outer quadrant Week 8: Left thigh, lower-outer quadrant After eight weeks, the cycle restarts

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Con reducciones ponderales de hasta el 22,5% en pacientes con obesidad sin diabetes, normalizacin glucmica en el 94,5% de los prediabticos a tres aos, reduccin del 38% en los eventos de insuficiencia cardiaca con fraccin de eyeccin preservada y no inferioridad cardiovascular frente a dulaglutida con seales de superioridad en mortalidad, tirzepatide representa el avance ms significativo en el tratamiento farmacolgico de la obesidad y sus complicaciones cardiovasculares de la ltima dcada