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Reactions were incubated for 30 minutes at room temperature in white, clear-bottom microtiter plates

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The randomized, double-blind trial found that daily supplementation with pasteurized Akkermansia muciniphila for three months resulted in reduced insulin resistance, decreased plasma total cholesterol, and modest improvements in body weight and fat mass compared to placebo

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Therefore, observed differences in cancer incidence may partially reflect avoidance of insulin exposure rather than a direct protective effect of GLP-1 RAs
Common adverse effects include nausea (reported in 20-44% of patients), vomiting, diarrhea, constipation, and abdominal discomfort
