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The answer is yes: clinical trials show semaglutide produces meaningful weight loss across the spectrum, with average reductions ranging from 5% to 15% of body weight depending on dose and adherence

Summary Fasting and GLP-1 work through similar appetite and metabolism pathways in the body

12, 2025 from Liu, B

The studies mostly had a moderate risk of bias, limiting the validity of the conclusions

Doctors sometimes recommend ESG for patients who: cannot tolerate GLP-1 medications experienced limited weight loss from medication therapy prefer a non-surgical alternative to bariatric surgery At EndoSlim Clinic NY , specialists evaluate each patient individually before recommending a procedure

Its a key part of protecting patient health