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A separate Phase 2a trial showed significant liver fat reduction in patients with MASLD/MASH

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Switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after starting medication and for 4 weeks after each dose escalation until you reach a maintenance dose

La Vignera S, Condorelli RA, Vicari E, DAgata R, Calogero AE

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Gastrointestinal manifestations of the persistent urge to pass stool often coincide with symptoms such as irregular bowels, recurring abdominal pain relieved by passing gas or having a bowel movement, and straining during bowel movements despite urgency
