best day of week to take glp 1 Should I GLP-1 in the Morning or at Night? How Long Does It Take

These medications work by mimicking the hormone GLP-1 to reduce appetite, slow gastric emptying, and improve insulin sensitivity

Mild-to-moderate diarrhea affects roughly 20% of GLP-1 users, while severe casesdefined as multiple loose stools daily that interfere with activitiesoccur in fewer than 5%

2023;8(10) doi: 10.1172/jci.insight.164921

Colsoul B, Schraenen A, Lemaire K et al (2010) Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

For individuals comparing both medications, you can learn more in our detailed guide Semaglutide Versus Tirzepatide

Additional trials in the TRIUMPH program may address retatrutide effects on cardiovascular outcomes, sleep apnea resolution, and kidney function, though these have not yet been formally announced